2,4-Dibromo-1-(2-bromoethoxy)benzene → HCID 11563691, compound

HRID 1782432Notes

Reaction equation

HRID 1782432 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][C:24]1[CH:29]=[C:28]([Br:30])[CH:27]=[CH:26][C:25]=1[O:31][CH2:32][CH2:33]Br>CC#N>[Br-:23].[Br:23][C:24]1[CH:29]=[C:28]([Br:30])[CH:27]=[CH:26][C:25]=1[O:31][CH2:32][CH2:33][N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2

Participants

4

Reactant 2

HCID 127251882,4-Dibromo-1-(2-bromoethoxy)benzeneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11563691HCID 11563691, compoundYield 52.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0557 g, 0.190 mmol) and 2-bromoethyl 2,4-dibromophenyl ether (0.110 g, 0.306 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0525 g, 43.8%). EI-MS m/z 572(M+) Rt (2.26 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c5fca3d9e23d4fc4968430762cb29c69
Source dataset
uspto-grants-2009_03
Patent number
US07498440B2

Reaction notes

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