1-(3-bromopropoxy)-4-nitrobenzene → HCID 11599275, compound

HRID 1782464Notes

Reaction equation

HRID 1782464 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[N+:23]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH2:34][CH2:35][Br:36])=[CH:28][CH:27]=1)([O-:25])=[O:24]>CC#N>[Br-:36].[OH:10][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:35][CH2:34][CH2:33][O:32][C:29]3[CH:30]=[CH:31][C:26]([N+:23]([O-:25])=[O:24])=[CH:27][CH:28]=3)([CH2:2][CH2:3]1)[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 2611281-(3-bromopropoxy)-4-nitrobenzeneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11599275HCID 11599275, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0468 g, 0.159 mmol) and 3-bromopropyl 4-nitrophenyl ether (0.0550 g, 0.211 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0590 g, 67.0%). EI-MS m/z 473(M+) Rt (2.06 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-94d23a24ee9446ed9f0dfe3890712622
Source dataset
uspto-grants-2009_03
Patent number
US07498440B2

Reaction notes

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