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1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol → 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| 反応物 | 3-[(3-bromopropyl)oxy]-N,N-diethylaniline | HCID 68963374 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 11534358 | 63% |
反応手順
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0257 g, 0.0876 mmol) and 3-[(3-bromopropyl)oxy]-N,N-diethylaniline (0.0314 g, 0.110 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.032.0 g, 63.0%). EI-MS m/z 500(M+) Rt (1.58 min).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07498440B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-13a6f94b14c7421494d2718790e0f673 |
| 出典メモ | uspto-grants-2009_03 |