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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1782532Generated: October 30, 2026

Ibuprofen, (+-)- → 2-(4-Isobutyl-phenyl)-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-propionamide

https://huagongshe.com/reaction/1782532

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIbuprofen, (+-)-HCID 3672—
Reactant4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamineHCID 11557499—
Product2-(4-Isobutyl-phenyl)-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-propionamideHCID 1844083263%

Reaction Steps

Pet-152 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using 2-(4-isobutyl-phenyl)-propionic acid (Ibuprofen) and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 63%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07498445B2
Source datasetuspto-grants-2009_03
ORD IDord-0e7089e2426d4560b96cf5fa1593444c
Source noteuspto-grants-2009_03