2,4-Dichlorophenylacetic acid → HCID 18440812, compound

HRID 1782538Notes

Reaction equation

HRID 1782538 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH3:13][C:14]1[N:15]=[C:16]([NH2:25])[S:17][C:18]=1[CH2:19][CH2:20][O:21][N+:22]([O-:24])=[O:23]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([NH:25][C:16]1[S:17][C:18]([CH2:19][CH2:20][O:21][N+:22]([O-:24])=[O:23])=[C:14]([CH3:13])[N:15]=1)=[O:12]

Participants

3

Reactant 2

HCID 882092,4-Dichlorophenylacetic acidHCID 115574994-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine

Product 1

HCID 18440812HCID 18440812, compoundYield 69%

Procedure

Pet-162 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using (2,4-dichloro-phenyl)-acetic acid and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 69%.

Workup

  1. customPet-162 was prepared
  2. customthe procedure described above for the preparation of Pet-154

Sources & evidence

ORD record
ord-23aa47d2cd68400c88d95fc1a3e6dbcc
Source dataset
uspto-grants-2009_03
Patent number
US07498445B2

Reaction notes

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