HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Agomelatine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-(7-Methoxynaphthalen-1-yl)ethan-1-amine hydrochloride | HCID 16050055 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Agomelatine | HCID 82148 | 92.5% |
Reaction Steps
173 kg of the compound obtained in Step C and 66 kg of sodium acetate in ethanol are introduced into a 1600 liter reactor. The mixture is stirred and then 79 kg of acetic anhydride are added; the reaction mixture is heated at reflux and 600 l of water are added. The reaction mixture is allowed to return to ambient temperature and the precipitate obtained is filtered off and washed with a 35/65 ethanol/water mixture to give the title product in a yield of 92.5% and with a chemical purity exceeding 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498466B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-622244ec24d0411ab05fdf9ec7365129 |
| Source note | uspto-grants-2009_03 |