反应详情

A solution of 58.0 g (0.151 mol) of methyl 4-[[[1-(phenylmethyl)-4-piperidinyl]amino]methyl]-3-nitrobenzoate in 800 ml of methanol was hydrogenated in the presence of 10 g of 5% rhodium/charcoal for 7 hours at room temperature. The catalyst was filtered off, the filtrate was evaporated down in vacuo. 50.0 g (93.7% of theory) of colourless crystals were obtained, which were further processed without any more purification.

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated down in vacuo
3. custom50.0 g (93.7% of theory) of colourless crystals were obtained
4. customwhich were further processed without any more purification