HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-Ethyl-4,4'-bipiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Ethyl-4-[1-(phenylmethoxycarbonyl)-4-piperidinyl]piperidine | HCID 18321284 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Ethyl-4,4'-bipiperidine | HCID 18321027 | — |
Reaction Steps
A solution of 7.6 g (0.023 mol) of 1-ethyl-4-[1-(phenylmethoxy-carbonyl)-4-piperidinyl]piperidine in a mixture of 70 ml of methanol, 30 ml of water and 10 ml of glacial acetic acid was hydrogenated in the presence of 10% palladium/charcoal at room temperature and 3 bar of hydrogen pressure until the uptake of hydrogen had ceased. After working up in the usual way the desired compound was obtained as a colourless oil in a quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498325B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-5a75cfbb2ebe4d1da82d9af7f8daad6f |
| Source note | uspto-grants-2009_03 |