Aluminium lithium hydride → HCID 18321094, compound

HRID 1782744Notes

Reaction equation

HRID 1782744 reaction equation
[CH3:1][N:2]([CH3:28])[C:3](=O)[CH2:4][CH2:5][C:6](=[O:26])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)=[CH:9][CH:8]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)(=O)C.CO>[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH:6]([C:7]1[CH:8]=[CH:9][C:10]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:17][CH2:18]2)=[CH:11][CH:12]=1)[OH:26]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57164664HCID 57164664, compound

Product 1

HCID 18321094HCID 18321094, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogously to example A51 from N,N-dimethyl-γ-oxo-4-[4-(phenylmethyl)-1-piperazinyl]-benzenebutanoic acid amide by reduction with lithium aluminium hydride in a yield of 61% of theory. Colourless, amorphous substance of Rf=0.62 (eluant:ethyl acetate/methanol 1/1 v/v).

Sources & evidence

ORD record
ord-a34a7206ec6d4187a9d8e2d9e29d451e
Source dataset
uspto-grants-2009_03
Patent number
US07498325B2

Reaction notes

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