Sodium Hydroxide → HCID 10257347, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 90.73 g of methyl 4-{3-[4-(3-cyclohexylpropoxy)phenyl]propoxy}-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate in 500 ml of THF and 500 ml of methanol is mixed with 300 ml of 2 molar sodium hydroxide solution and heated to 60° C. After one hour, the organic solvents are removed as far as possible in a rotary evaporator. 325 ml of 2 molar hydrochloric acid are added to the residue with stirring. A precipitate separates out during this and is filtered off with suction and washed with water. The product is purified by recrystallization from a mixture of 500 ml of acetone and 1000 ml of water. 77.5 g of product are obtained. m.p.: 160° C.

Provenance & Evidence