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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1782776Generated: October 30, 2026

methyl (1R,3S)-3-aminocyclopentane-1-carboxylate hydrochloride → Ethyl 4-{3-[4-(biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({[(1S,3R)-3-(methoxycarbonyl)cyclopentyl]amino}carbonyl)benzoate

https://huagongshe.com/reaction/1782776

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl (1R,3S)-3-aminocyclopentane-1-carboxylate hydrochlorideHCID 57463822—
ReactantHCID 57589042HCID 57589042—
ProductEthyl 4-{3-[4-(biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({[(1S,3R)-3-(methoxycarbonyl)cyclopentyl]amino}carbonyl)benzoateHCID 57589188—

Reaction Steps

Preparation takes place in analogy to Example 5 from 2-{3-[4-(1,1′-biphenyl-4-yl-methoxy)phenyl]propoxy}-5-(ethoxycarbonyl)benzoic acid and methyl (1R,3S)-3-aminocyclopentanecarboxylate hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07498460B2
Source datasetuspto-grants-2009_03
ORD IDord-5fedf11f68214768abfdd9f513edcbe2
Source noteuspto-grants-2009_03