HRID1782780

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19363746

1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene

C11H13ClO

结构：COC(=O)c1ccc(OCCCc2ccc(O)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589128

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(OCCCc2ccc(OCc3ccc(OCC4CC4)cc3)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589244

未命名化合物

PROCEDURE

实验过程

Methyl 4-[3-(4-{[4-(cyclopropylmethoxy)benzyl]oxy}phenyl)propoxy]-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate is prepared in analogy to the process described in Example 34 from methyl 4-[3-(4-hydroxyphenyl)propoxy]-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate and 1-(chloromethyl)-4-(cyclopropylmethoxy)benzene.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be05247ab3ed4304ab69c202b3792640
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07498460B2
来源说明: uspto-grants-2009_03

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[C:22]([NH:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]2)=[O:23])=[CH:4][CH:3]=1.Cl[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][CH2:44][CH:45]2[CH2:47][CH2:46]2)=[CH:39][CH:38]=1>>[CH:45]1([CH2:44][O:43][C:40]2[CH:39]=[CH:38][C:37]([CH2:36][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]4[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=4[C:22]([NH:24][CH:25]4[CH2:30][CH2:29][CH2:28][CH:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]4)=[O:23])=[CH:4][CH:3]=3)=[CH:42][CH:41]=2)[CH2:46][CH2:47]1