Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1782786Generated: October 30, 2026

4-(Trifluoromethoxy)benzyl Chloride → Methyl 3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)-4-[3-(4-{[4-(trifluoromethoxy)benzyl]oxy}phenyl)propoxy]benzoate

https://huagongshe.com/reaction/1782786

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)benzyl ChlorideHCID 2777261—
ReactantHCID 57589128HCID 57589128—
ProductMethyl 3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)-4-[3-(4-{[4-(trifluoromethoxy)benzyl]oxy}phenyl)propoxy]benzoateHCID 57589149—

Reaction Steps

Methyl 3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)-4-[3-(4-{[4-(trifluoromethoxy)benzyl]oxy}phenyl)propoxy]benzoate is prepared in analogy to the process described in Example 34 from methyl 4-[3-(4-hydroxyphenyl)propoxy]-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate and 1-(chloromethyl)-4-trifluoromethoxybenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07498460B2
Source datasetuspto-grants-2009_03
ORD IDord-1b95eed16c7a4451851b066b5d82da3d
Source noteuspto-grants-2009_03