HRID1782787

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9881136

1-(3-bromopropyl)-4-chlorobenzene

C9H10BrCl

结构：COC(=O)c1ccc(OCCCc2ccc(O)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589128

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(OCCCc2ccc(OCCCc3ccc(Cl)cc3)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589159

未命名化合物

PROCEDURE

实验过程

Methyl 4-(3-{4-[3-(4-chlorophenyl)propoxy]phenyl}propoxy)-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate is prepared in analogy to the process described in Example 34 from methyl 4-[3-(4-hydroxyphenyl)propoxy]-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate and 1-(3-bromopropyl)-4-chlorobenzene.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1eec3f42f5ac492aa0ff2f92ef5f3933
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07498460B2
来源说明: uspto-grants-2009_03

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[C:22]([NH:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]2)=[O:23])=[CH:4][CH:3]=1.Br[CH2:36][CH2:37][CH2:38][C:39]1[CH:44]=[CH:43][C:42]([Cl:45])=[CH:41][CH:40]=1>>[Cl:45][C:42]1[CH:43]=[CH:44][C:39]([CH2:38][CH2:37][CH2:36][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]3[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=3[C:22]([NH:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]3)=[O:23])=[CH:4][CH:3]=2)=[CH:40][CH:41]=1