HCID 57589233, compound → Ethyl 3-{[3-(2-ethoxy-2-oxoethyl)azetidin-1-yl]carbonyl}-4-{3-[4-(4-phenoxybutoxy)phenyl]-propoxy}benzoate

HRID 1782790Notes

Reaction equation

HRID 1782790 reaction equation
[Cl-].[CH2:2]([O:4][C:5](=[O:11])[CH2:6][CH:7]1[CH2:10][NH2+:9][CH2:8]1)[CH3:3].[CH2:12]([O:14][C:15]([C:17]1[CH:18]=[CH:19][C:20]([O:26][CH2:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:37][CH2:38][CH2:39][CH2:40][O:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)=[CH:32][CH:31]=2)=[C:21]([CH:25]=1)[C:22](O)=[O:23])=[O:16])[CH3:13]>>[CH2:2]([O:4][C:5](=[O:11])[CH2:6][CH:7]1[CH2:10][N:9]([C:22]([C:21]2[CH:25]=[C:17]([CH:18]=[CH:19][C:20]=2[O:26][CH2:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:37][CH2:38][CH2:39][CH2:40][O:41][C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)=[CH:32][CH:31]=2)[C:15]([O:14][CH2:12][CH3:13])=[O:16])=[O:23])[CH2:8]1)[CH3:3]

Participants

3

Reactant 2

HCID 57589233HCID 57589233, compoundHCID 69072402Ethyl 2-(3-azetidinyl)acetate Hydrochloride

Product 1

HCID 57589055Ethyl 3-{[3-(2-ethoxy-2-oxoethyl)azetidin-1-yl]carbonyl}-4-{3-[4-(4-phenoxybutoxy)phenyl]-propoxy}benzoate

Procedure

Preparation takes place in analogy to Example IX, method 3, from 3-(2-ethoxy-2-oxoethyl)azetidinium chloride and 5-(ethoxycarbonyl)-2-{3-[4-(4-phenoxybutoxy)-phenyl]propoxy}benzoic acid.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-51230e606b3b4fce94023cc2d0eabd29
Source dataset
uspto-grants-2009_03
Patent number
US07498460B2

Reaction notes

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