HCID 57589154, compound → Methyl 4-{2-[4-(biphenyl-4-ylmethoxy)phenoxy]ethoxy}-3-({[3-(methoxycarbonyl)-cyclohexyl]amino}carbonyl)benzoate

HRID 1782791Notes

Reaction equation

HRID 1782791 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[C:12]([NH:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([O:23][CH3:24])=[O:22])[CH2:16]1)=[O:13].Br[CH2:26][CH2:27][O:28][C:29]1[CH:48]=[CH:47][C:32]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)=[CH:37][CH:36]=2)=[CH:31][CH:30]=1>>[C:38]1([C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH:39]=[CH:40][C:35]([CH2:34][O:33][C:32]2[CH:47]=[CH:48][C:29]([O:28][CH2:27][CH2:26][O:1][C:2]3[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=3[C:12]([NH:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([O:23][CH3:24])=[O:22])[CH2:16]3)=[O:13])=[CH:30][CH:31]=2)=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 57589154HCID 57589154, compoundHCID 57589182Methyl 4-hydroxy-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate

Product 1

HCID 57589118Methyl 4-{2-[4-(biphenyl-4-ylmethoxy)phenoxy]ethoxy}-3-({[3-(methoxycarbonyl)-cyclohexyl]amino}carbonyl)benzoate

Procedure

Preparation takes place in analogy to Example 22 from the (+)-B-enantiomer of methyl 4-hydroxy-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate (see Example IX, method 2) and 4-{[4-(2-bromoethoxy)phenoxy]methyl}biphenyl.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-7b23d17ccdeb4338becb61ce1f456aba
Source dataset
uspto-grants-2009_03
Patent number
US07498460B2

Reaction notes

Loading…