HCID 57589160, compound → HCID 57589057, compound

HRID 1782799Notes

Reaction equation

HRID 1782799 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[C:12]([NH:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([O:23][CH3:24])=[O:22])[CH2:16]1)=[O:13].[C:25]1([O:31][CH2:32][CH2:33][CH2:34]/[CH:35]=[CH:36]/[C:37]2[CH:42]=[CH:41][C:40]([CH2:43][CH2:44][CH2:45]Br)=[CH:39][CH:38]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH3:24][O:23][C:21]([CH:17]1[CH2:18][CH2:19][CH2:20][CH:15]([NH:14][C:12]([C:3]2[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=2[O:1][CH2:45][CH2:44][CH2:43][C:40]2[CH:41]=[CH:42][C:37](/[CH:36]=[CH:35]/[CH2:34][CH2:33][CH2:32][O:31][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:38][CH:39]=2)[C:6]([O:8][CH3:9])=[O:7])=[O:13])[CH2:16]1)=[O:22]

Participants

3

Reactant 2

HCID 57589160HCID 57589160, compoundHCID 57589182Methyl 4-hydroxy-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate

Product 1

HCID 57589057HCID 57589057, compound

Procedure

Preparation takes place in analogy to Example 22 from the (+)-B-enantiomer of methyl 4-hydroxy-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate (see Example IX, method 2) and (4E)-5-[4-(3-bromopropyl)phenyl]pent-4-en-1-yl phenyl ether.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-0609e73e29a54275990065659001773f
Source dataset
uspto-grants-2009_03
Patent number
US07498460B2

Reaction notes

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