HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid → N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid | HCID 22593642 | — |
| Reactant | (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol Trifluoroacetate | HCID 69869154 | — |
| Product | N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide | HCID 68607391 | — |
Reaction Steps
Following the general procedure of EXAMPLEs 6 and making non-critical variations and using (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol (VIII, EXAMPLE 5) with 5-(dipropylamino)-5-oxopentanoic acid (IX), the title compound is obtained, MH+=534.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498436B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-58c617337dde4983b00cc67a19472259 |
| Source note | uspto-grants-2009_03 |