HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydro-1-naphthylamine → N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isobutoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydro-1-naphthylamine | HCID 18066 | — |
| Reactant | HCID 10131699 | HCID 10131699 | — |
| Reactant | 3-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid | HCID 22593642 | — |
| Product | N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isobutoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide | HCID 69413411 | — |
Reaction Steps
Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V), H2N—CH2-phenyl-O-i-butyl (VI) and “5-Me-PHTH” (IX), the title compound is obtained, MH+=624.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07498436B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-d0513e3bdf4b4036a27a41877ea30055 |
| Source note | uspto-grants-2009_03 |