1,2,3,4-Tetrahydro-1-naphthylamine → N1-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-N3-methyl-N3-propylisophthalamide

Participants

Reaction Steps

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V), H2N—CH2-phenyl (VI) and (CH3—CH2—CH2—)(CH3—)N—CO—(CH3-)phenyl-CO—OH (IX) where the attachment to the -phenyl- ring for the carbonyls is 1-,3- and 5- for the methyl group, the title compound is obtained, MH+=510.

Provenance & Evidence