HCID 10131699, compound → HCID 57511926, compound

HRID 1783216Notes

Reaction equation

HRID 1783216 reaction equation
F[C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:14][C:15](=[O:24])OCC2C=CC=CC=2)[C@H:11]2[CH2:13][O:12]2)[CH:5]=[C:6](F)[CH:7]=1.[CH3:25][O:26][C:27]1[CH:36]=[C:35]2[C:30](CCC[CH:34]2[NH2:37])=[CH:29][CH:28]=1.C(N(CCC)C([C:44]1[CH:45]=[C:46]([CH:50]=[C:51](CC)[CH:52]=1)[C:47]([OH:49])=O)=O)CC>>[CH2:9]([C@H:10]([NH:14][C:15](=[O:24])[C:2]1[CH:3]=[CH:4][C:5]([O:49][CH2:47][C:46]2[CH:45]=[CH:44][CH:52]=[CH:51][CH:50]=2)=[CH:6][CH:7]=1)[C@H:11]([OH:12])[CH2:13][NH:37][CH2:34][C:35]1[CH:30]=[CH:29][CH:28]=[C:27]([O:26][CH3:25])[CH:36]=1)[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 10131699HCID 10131699, compoundHCID 139145927-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 225936423-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid

Product 1

HCID 57511926HCID 57511926, compound

Procedure

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl 1-(2-oxiranyl)-2-phenylethylcarbamate (V), 3-methoxybenzylamine (VI) and 4-(benzyloxy)benzoic acid (IX), the title compound is obtained, MH+=511.

Sources & evidence

ORD record
ord-881d3376363944babe3e787195dd6870
Source dataset
uspto-grants-2009_03
Patent number
US07498436B2

Reaction notes

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