tert-Butyl ((S)-2-(3,5-difluorophenyl)-1-((S)-oxiran-2-yl)ethyl)carbamate → HCID 68608047, compound

HRID 1783217Notes

Reaction equation

HRID 1783217 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:14][C:15](=[O:21])OC(C)(C)C)[C@H:11]2[CH2:13][O:12]2)[CH:5]=[C:6]([F:8])[CH:7]=1.C[O:23][C:24]1[CH:33]=[C:32]2[C:27](CCC[CH:31]2[NH2:34])=CC=1.[CH2:35]([N:38]([CH2:52][CH2:53][CH3:54])[C:39]([C:41]1[CH:42]=[C:43]([CH:47]=[C:48]([CH2:50]C)[CH:49]=1)C(O)=O)=[O:40])[CH2:36][CH3:37]>>[F:8][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([F:1])[CH:7]=1)[CH2:9][C@H:10]([NH:14][C:15](=[O:21])[C:43]1[CH:47]=[C:48]([CH3:50])[CH:49]=[C:41]([C:39]([N:38]([CH2:35][CH2:36][CH3:37])[CH2:52][CH2:53][CH3:54])=[O:40])[CH:42]=1)[C@H:11]([OH:12])[CH2:13][NH:34][CH2:31][C:32]1[CH:33]=[CH:24][O:23][CH:27]=1

Participants

4

Reactant 3

HCID 9922319tert-Butyl ((S)-2-(3,5-difluorophenyl)-1-((S)-oxiran-2-yl)ethyl)carbamateHCID 139145927-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 225936423-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid

Product 1

HCID 68608047HCID 68608047, compound

Procedure

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V, EXAMPLE 3), 3-furylmethylamine (VI) and “5-Me-PHTH” (IX), the title compound is obtained, MH+=542.

Sources & evidence

ORD record
ord-e2d3c2a7faa443688651def880300bfc
Source dataset
uspto-grants-2009_03
Patent number
US07498436B2

Reaction notes

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