1-Aminotetralin, (S)- → HCID 68607028, compound

HRID 1783221Notes

Reaction equation

HRID 1783221 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:14][C:15](=[O:24])OCC2C=CC=CC=2)[C@H:11]2[CH2:13][O:12]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[C@@H:25]1([NH2:35])[C:34]2[C:29](=CC=CC=2)[CH2:28][CH2:27][CH2:26]1.[CH2:36]([N:39]([CH2:53][CH2:54][CH3:55])[C:40]([C:42]1[CH:43]=[C:44]([CH:48]=[C:49]([CH2:51]C)[CH:50]=1)C(O)=O)=[O:41])[CH2:37][CH3:38]>>[NH:35]([CH2:13][C@@H:11]([OH:12])[C@@H:10]([NH:14][C:15](=[O:24])[C:44]1[CH:48]=[C:49]([CH3:51])[CH:50]=[C:42]([C:40]([N:39]([CH2:36][CH2:37][CH3:38])[CH2:53][CH2:54][CH3:55])=[O:41])[CH:43]=1)[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[C:25]1[CH:34]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 3

HCID 70580741-Aminotetralin, (S)-HCID 10131699HCID 10131699, compoundHCID 225936423-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid

Product 1

HCID 68607028HCID 68607028, compound

Procedure

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V), aniline (VI) and and “5-Me-PHTH” (IX), the title compound is obtained, MH+=538.

Sources & evidence

ORD record
ord-a3c6b0881eba41dbad393ebfae961605
Source dataset
uspto-grants-2009_03
Patent number
US07498436B2

Reaction notes

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