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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 178325Generated: October 27, 2026

Methanol → 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

https://huagongshe.com/reaction/178325

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantMethylhydrazineHCID 6061—
ReactantChlorotrimethylsilaneHCID 6397—
Reactant1,3-Dimethyl-2-imidazolidinoneHCID 6661—
ReactantHydrogen iodideHCID 24841—
ReactantMagnesiumHCID 5462224—
ReactantMethyl 3-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylateHCID 44473215—
ReactantMethyl 2-difluoromethyl-1-methylpyrazole-3-carboxylateHCID 66738668—
ReactantMethyl 2-methoxymethylene-4,4,4-trifluoro-3-oxobutyrateHCID 86640098—
Product3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acidHCID 18983008—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-1780bb594369498b86ffbde79d62826a
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)