N-bromobutanimide → HCID 23084641, compound

Participants

Reaction Steps

1,3-Dimethyl-5-methoxymethoxy-3H-pyrazolo[3,4-c]isoquinoline (1.03 g), N-bromosuccinimide (0.72 g) and benzoyl peroxide (0.05 g) were dissolved in carbon tetrachloride (20 mL), and the mixture was heated under reflux for 4 hrs. After the completion of the reaction, the reaction mixture was cooled to room temperature, washed with saturated aqueous sodium hydrogen carbonate and dried over magnesium sulfate. The solvent was evaporated. The obtained solid was collected by filtration and washed with ether to give 1-bromomethyl-3-methyl-5-methoxymethoxy-3H-pyrazolo[3,4-c]isoquinoline (1.0 g).

Provenance & Evidence