Methylhydrazine → HCID 23084651, compound

HRID 1783300Notes

Reaction equation

HRID 1783300 reaction equation
[C:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[C:5]#[N:6])(=O)[CH3:2].[CH3:14][NH:15][NH2:16]>C(O)C>[NH2:6][C:5]1[N:15]([CH3:14])[N:16]=[C:1]([CH3:2])[C:4]=1[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 30138862-(4-Fluorophenyl)-3-oxobutanenitrile

Product 1

HCID 23084651HCID 23084651, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

α-Acetyl-4-fluorophenylacetonitrile (65.1 g) and methylhydrazine (30.9 mL) were dissolved in ethanol (320 mL), and the mixture was heated under reflux for 3 hrs. After the completion of the reaction, the reaction mixture was cooled to room temperature, and the solvent was evaporated. The obtained solid was collected by filtration and washed with hexane to give 5-amino-4-(4-fluorophenyl)-1,3-dimethylpyrazole (69.5 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customAfter the completion of the reaction
  4. customthe solvent was evaporated
  5. filtrationThe obtained solid was collected by filtration
  6. washwashed with hexane

Sources & evidence

ORD record
ord-cddb9af07abf41b494cfeb8ed3d46cb9
Source dataset
uspto-grants-2009_03
Patent number
US07501412B2

Reaction notes

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