反应详情

α-Acetylphenylacetonitrile (10 g) was dissolved in methanol (100 mL), and hydrazinoethanol (5.3 g) was added, and the mixture was heated under reflux for 4 hrs. After the completion of the reaction, the solvent was evaporated. The obtained residue was subjected to silica gel column chromatography, and the fraction eluted with chloroform:methanol=40:1 was concentrated to give 5-amino-1-(2-hydroxyethyl)-3-methyl-4-phenylpyrazole (11.4 g) as white crystals.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 4 hrs
3. customAfter the completion of the reaction
4. customthe solvent was evaporated
5. washthe fraction eluted with chloroform
6. concentrationmethanol=40:1 was concentrated