Water → HCID 23084610, compound

Participants

Reaction Steps

Sodium hydride (purity 60%, 2.0 g) was suspended in dimethylformamide (100 mL), and trimethylsulfoxonium iodide (11 g) was added, and the mixture was stirred at room temperature for 1 hr. Then, methyl 2-isonicotinoylbenzoate (11 g) was added, and the mixture was further stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the precipitated crystals were collected by filtration to give 4-(pyridin-4-yl)isocoumarin (4.9 g).

Provenance & Evidence