Ammonia → HCID 23084821, compound

Participants

Reaction Steps

4-(Pyridin-4-yl)isocoumarin (4.9 g) was suspended in ethanol and 28% aqueous ammonia, and the mixture was heated under reflux for 1 hr. Concentrated hydrochloric acid was added to acidify the reaction mixture, and the mixture was further stirred at room temperature for 1 hr. After the completion of the reaction, aqueous potassium carbonate solution was added to the reaction mixture, and the mixture was extracted with a mixed solvent (chloroform:methanol=10:1). The organic layer was dried over magnesium sulfate. The solvent was evaporated, and the obtained residue was collected by filtration to give 4-(pyridin-4-yl)-2H-isoquinolin-1-one (2.9 g).

Provenance & Evidence