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HRID 1783330作成日：2026年10月25日

1-[2-Nitro-4-(trifluoromethyl)phenyl]piperazine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

https://huagongshe.com/reaction/1783330

反応式

関与物質

役割名称HCID仕込み量
反応物1-[2-Nitro-4-(trifluoromethyl)phenyl]piperazineHCID 2771407—
反応物2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamideHCID 22379151—
溶媒AcetonitrileHCID 6342—
生成物N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamideHCID 22353518—

反応手順

2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (100 mg) was dissolved in acetonitrile (5 ml) and (4-trifluromethyl-2-nitrophenyl)piperazine (253 mg) added. The solution was stirred overnight at room temperature. After this time the solvent was removed in vacuo. Purification by flash chromatography on silica gel eluting with a mixture of dichloromethane and methanol (98:2, then 93:7 v/v) afforded the title compound. m/z (ES+) 521 (MH)+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07501407B2
出典データセットuspto-grants-2009_03
ORD IDord-5c6c184e1d684d56a0e5c98b1dbafb7f
出典メモuspto-grants-2009_03