Acetonitrile → 2-[4-(4-tert-Butylbenzyl)piperazin-1-yl]-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide

Participants

Reaction Steps

To a stirred solution of 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (0.80 g in 40 ml acetonitrile) was added [(2E)-3-phenylprop-2-enyl]piperazine (0.50 g in 10 ml acetonitrile). After 3 hrs, N,N-diisopropylethylamine was added (428 μl in 10 ml acetonitrile) and the reaction stirred for a further 2 hrs after which time a precipitate of the title compound appeared. This was used crude in the next step.

Provenance & Evidence