HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-(Bromomethyl)phenyl)isoxazole → 4-chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-(Bromomethyl)phenyl)isoxazole | HCID 22997545 | — |
| Reactant | 4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide | HCID 57589901 | — |
| Product | 4-chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide | HCID 68623493 | — |
Reaction Steps
4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide was alkylated using 5-(4-bromomethyl-phenyl)-isoxazole analogous to Example 1 to afford 4-chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide: MS: m/e=496.0 (MH+), 513.2 (MNH4+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501406B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-ab4db7aaf0e0490e9940c0a17b51a6fc |
| Source note | uspto-grants-2009_03 |