HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide → 4-chloro-N-(4-difluoromethyl-benzyl)-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide | HCID 57589901 | — |
| Reactant | 1-(Bromomethyl)-4-(difluoromethyl)benzene | HCID 57589907 | — |
| Product | 4-chloro-N-(4-difluoromethyl-benzyl)-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide | HCID 68623419 | — |
Reaction Steps
4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide was alkylated using 1-bromomethyl-4-difluoromethyl-benzene analogous to Example 1 to afford 4-chloro-N-(4-difluoromethyl-benzyl)-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501406B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-c5aa9f9ae3284910bd874e669028f008 |
| Source note | uspto-grants-2009_03 |