Ethanol → HCID 68625251, compound

HRID 1783408Notes

Reaction equation

HRID 1783408 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][C:24]=2[F:31])[C@@H:12]2[CH2:18][C:17]([F:20])([F:19])[CH2:16][CH2:15][NH:14][C:13]2=[O:21])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:32]([OH:34])[CH3:33]>>[ClH:1].[CH2:32]([O:34][C:29](=[NH:30])[C:26]1[CH:27]=[CH:28][C:23]([CH2:22][N:11]([S:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)(=[O:9])=[O:10])[C@@H:12]2[CH2:18][C:17]([F:20])([F:19])[CH2:16][CH2:15][NH:14][C:13]2=[O:21])=[C:24]([F:31])[CH:25]=1)[CH3:33]

Participants

3

Reactant 2

HCID 702EthanolHCID 68624063HCID 68624063, compound

Product 1

HCID 68625251HCID 68625251, compound

Conditions

Temperature
0 °C

Procedure

4-Chloro-N-(4-cyano-2-fluoro-benzyl)-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-benzenesulfonamide (0.23 g, 0.49 mmol) was suspended in dry ethanol (10 ml) and cooled to 0° C. Dry HCl gas was gently bubbled over 30 min into this suspension. The light red reaction mixture was stirred at room temperature for 20 h. A clear yellow solution resulted which was concentrated under reduced pressure and the crude was used directly in the next step: 0.28 g; MS: m/e=516.2 (MH−).

Workup

  1. customDry HCl gas was gently bubbled over 30 min into this suspension
  2. customThe light red reaction mixture
  3. customA clear yellow solution resulted which
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-7c2fa5f091a84e0c9ee9814151a9b65d
Source dataset
uspto-grants-2009_03
Patent number
US07501406B2

Reaction notes

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