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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783452Generated: November 1, 2026

(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-Methyl-3-(4-pyrazin-2-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester

https://huagongshe.com/reaction/1783452

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-oneHCID 5825354—
ReactantHCID 178468864HCID 178468864—
ReactantHCID 178469037HCID 178469037—
Product4-Methyl-3-(4-pyrazin-2-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 68612539—

Reaction Steps

3-dimethylamino-1-pyrazin-2-yl-propenone prepared in Preparation 2 and 3-guanidino-4-methylbenzoic acid ethyl ester nitrate were used instead 3-dimethylamino-1-pyridin-3-yl-propenone and 4-guanidino-benzoic acid ethyl ester nitrate according to the similar procedure to Preparation 8 to give the titled compound as yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501424B2
Source datasetuspto-grants-2009_03
ORD IDord-0a3ab26ef0c94b18b0dc85955333fe47
Source noteuspto-grants-2009_03