4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → HCID 68850957, compound

HRID 1783458Notes

Reaction equation

HRID 1783458 reaction equation
C([O:3][C:4](=[O:26])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([NH:12][C:13]2[N:18]=[C:17]([C:19]3[C:24]([CH3:25])=[N:23][CH:22]=[CH:21][N:20]=3)[CH:16]=[CH:15][N:14]=2)[CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:26])=[O:3])=[CH:6][C:7]=1[NH:12][C:13]1[N:18]=[C:17]([C:19]2[C:24]([CH3:25])=[N:23][CH:22]=[CH:21][N:20]=2)[CH:16]=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 143469694-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 68850774HCID 68850774, compound

Product 1

HCID 68850957HCID 68850957, compound

Procedure

4-methyl-3-[4-(3-methylpyrazin-2-yl)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 13 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Sources & evidence

ORD record
ord-1245f40d675a47ceb434cdcd2e539165
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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