4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → HCID 68849273, compound

HRID 1783459Notes

Reaction equation

HRID 1783459 reaction equation
C([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[N:17]=[C:16]([C:18]3[C:23]([CH3:24])=[N:22][CH:21]=[CH:20][N:19]=3)[CH:15]=[CH:14][N:13]=2)=[CH:7][CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[CH3:24][C:23]1[C:18]([C:16]2[CH:15]=[CH:14][N:13]=[C:12]([NH:11][C:8]3[CH:9]=[CH:10][C:5]([C:4]([OH:25])=[O:3])=[CH:6][CH:7]=3)[N:17]=2)=[N:19][CH:20]=[CH:21][N:22]=1

Participants

3

Reactant 2

HCID 143469694-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 68850341HCID 68850341, compound

Product 1

HCID 68849273HCID 68849273, compound

Procedure

4-[4-(3-methylpyrazin-2-yl)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 14 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Sources & evidence

ORD record
ord-638da218e91b46e8a69f4efdbb435f4a
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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