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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783461Generated: October 31, 2026

4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 4-[4-(Thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid

https://huagongshe.com/reaction/1783461

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 14346969—
Reactant4-[4-(Thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl esterHCID 86619755—
Product4-[4-(Thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acidHCID 86619754—

Reaction Steps

4-[4-(thiazol-2-ylamino)-pyrimidin-2-ylamino]-benzoic acid ethyl ester prepared in Preparation 16 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501424B2
Source datasetuspto-grants-2009_03
ORD IDord-8c9b23c6a59349498e1b6178ffc413a0
Source noteuspto-grants-2009_03