4-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester → 3-(4-Imidazol-1-yl-pyrimidin-2-ylamino)-4-methylbenzoic acid

HRID 1783462Notes

Reaction equation

HRID 1783462 reaction equation
C([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([NH:12][C:13]2[N:18]=[C:17]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=1)C.C(OC(=O)C1C=CC(NC2N=C(C3C=NC=CC=3)C=CN=2)=CC=1)C>>[N:19]1([C:17]2[CH:16]=[CH:15][N:14]=[C:13]([NH:12][C:7]3[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=3[CH3:11])[C:4]([OH:24])=[O:3])[N:18]=2)[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

3

Reactant 2

HCID 143469694-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl esterHCID 688516303-(4-Imidazol-1-yl-pyrimidin-2-ylamino)-4-methylbenzoic acid ethyl ester

Product 1

HCID 688523063-(4-Imidazol-1-yl-pyrimidin-2-ylamino)-4-methylbenzoic acid

Procedure

3-(4-imidazol-1-yl-pyrimidin-2-ylamino)-4-methylbenzoic acid ethyl ester prepared in Preparation 17 was used instead of 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid ethyl ester according to the similar procedure to Preparation 19 to give the titled compound as yellow solid.

Sources & evidence

ORD record
ord-90937b088d3d4aa2bbcc9ba53a79bd37
Source dataset
uspto-grants-2009_03
Patent number
US07501424B2

Reaction notes

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