HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-[5-(Phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 57590542 | HCID 57590542 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[5-(Phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester | HCID 57590540 | — |
Reaction Steps
To a solution of 4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (4) in MeOH cooled to 0 degree is LiOH, and the mixture is stirred overnight. After removal of MeOH, the residue is acidified with HCl, extracted with EA, dried and concentrated to give the corresponding 4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501422B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-e7b0ae02522245aa92fb381a63fa066a |
| Source note | uspto-grants-2009_03 |