Sodium Carbonate → HCID 66915942, compound

Participants

Reaction Steps

To a solution of (2,4-difluoro-phenyl)-tetrazole (0.44 g, 1.1 mmol) in 5 ml DMF was added 0.1 g (0.55 mmol) of (2S,4R)-2-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-4-(toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester and anhydrous sodium carbonate (0.15 g, 1.4 mmol). The mixture was stirred vigorously at 60 degree overnight. The solution was diluted with 30 ml EA and washed with 1M Na2CO3, 5% citric acid and brine, dried and concentrated to give the crude product as yellow oil (0.14 g, 0.34 mmol). MS m/e=410.3 [M+H]+.

Provenance & Evidence