Acetic Acid → HCID 25119234, compound

Participants

Reaction Steps

2-(4-{4-[5-(2,4-Difluoro-phenyl)-tetrazol-2-yl]-pyrrolidine-2-carbonyl}-piperazin-1-yl)-benzonitrile (0.136 g, 0.29 mmol), benzaldehyde (0.034 g, 0.32 mmol) and acetic acid (cat) was dissolved in DCM (20 ml) and the solution was stirred for 20 min. Then NaBH(OAc)3 (0.12 g, 0.58 mmol) was carefully added. The resulting mixture was warmed to r.t and stirred overnight. The solution was then washed with sat NaHCO3, brine, dried and concentrated to afford the title product as yellow oil (0.15 g, 6 mmol). MS m/e=555.4 [M+H]+.

Provenance & Evidence