HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783486Generated: October 29, 2026
Potassium Carbonate → HCID 57590535, compound
https://huagongshe.com/reaction/1783486
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Naphthalenethiol | HCID 68259 | — |
| Reactant | HCID 57590526 | HCID 57590526 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57590535 | HCID 57590535 | 31% |
Reaction Steps
A mixture of 4-(5-iodobenzoxazol-2-yl)piperazine-1-carboxylic acid benzyl ester, prepared in Example 2 (1.48 mmol theory), 1-napthalenethiol (0.237 g, 1.48 mmol), CuI (0.042 g, 0.22 mmol), and K2CO3 (0.409 g, 2.96 mmol) in isopropanol was heated at 90° C. overnight, diluted with 20% MeOH in CH2Cl2, and filtered through a pad of silica gel. The filtrate was concentrated to dryness. The resultant residue was purified by chromatography with 5% MeOH in CH2Cl2 to provide the title compound (230 mg, 31% overall yield from 4-benzoxazol-2-yl-piperazine-1-carboxylic acid benzyl ester), characterized by NMR and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07501421B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-8b005d31478d4b1bb3a11fdf7a2d4054 |
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| Source note | uspto-grants-2009_03 |
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