Benzyl piperazine-1-carboxylate → HCID 57590537, compound

HRID 1783488Notes

Reaction equation

HRID 1783488 reaction equation
[N+:1]([C:4]1[C:9]2[NH:10][C:11](=S)[O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[N:14]1([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH2:23]([O:22][C:20]([N:14]1[CH2:19][CH2:18][N:17]([C:11]2[O:12][C:8]3[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[C:9]=3[N:10]=2)[CH2:16][CH2:15]1)=[O:21])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 643495Benzyl piperazine-1-carboxylateHCID 22666196HCID 22666196, compound

Product 1

HCID 57590537HCID 57590537, compound

Procedure

A mixture of 4-nitro-3H-benzoxazole-2-thione (7.00 g, 35.7 mmol) and benzyl 1-piperazinecarboxylate (15.72 g, 71.36 mmol) in xylenes was heated at reflux temperature overnight, cooled and concentrated in vacuo to provide the title compound which was used, without further purification, in Example 8.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature overnight
  3. temperaturecooled
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2db2ddd664ff4ee0a45b1eb1ec313f00
Source dataset
uspto-grants-2009_03
Patent number
US07501421B2

Reaction notes

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