HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783496Generated: October 25, 2026
Hydrochloric Acid → 4-(6-Aminobenzothiazol-2-yl)piperazine-1-carboxylic acid benzyl ester
https://huagongshe.com/reaction/1783496
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-(6-Nitrobenzothiazol-2-yl)piperazine-1-carboxylic acid benzyl ester | HCID 15027801 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(6-Aminobenzothiazol-2-yl)piperazine-1-carboxylic acid benzyl ester | HCID 15027802 | 77% |
Reaction Steps
A mixture of 4-(6-nitrobenzothiazol-2-yl)piperazine-1-carboxylic acid benzyl ester (1.13 g, 2.84 mmol), SnCl2 (2.56 g, 11.3 mmol), and conc. HCl (0.35 mL, 4.25 mmol) in EtOH was heated at 70° C. overnight, diluted with water, neutralized with 1 N NaOH to pH 10, and extracted with CH2Cl2. The combined extracts were filtered through a pad of silica gel. The filtrate was concentrated in vacuo to provide the title compound (0.80 g, 77%), characterized by NMR and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07501421B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-2785adce26aa4f3cb36dcb4fb2aa1cc0 |
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| Source note | uspto-grants-2009_03 |
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