N-(4-Pyridylmethyl)ethylenediamine → HCID 68859643, compound

HRID 1783538Notes

Reaction equation

HRID 1783538 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16](S(C)=O)=[N:17][CH:18]=3)[NH:13][C:12]2=[O:24])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[N:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH:32][CH2:33][CH2:34][NH2:35])=[CH:27][CH:26]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16]([NH:35][CH2:34][CH2:33][NH:32][CH2:31][C:28]4[CH:27]=[CH:26][N:25]=[CH:30][CH:29]=4)=[N:17][CH:18]=3)[NH:13][C:12]2=[O:24])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

3

Reactant 2

HCID 81575N-(4-Pyridylmethyl)ethylenediamineHCID 570581323-(3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one

Product 1

HCID 68859643HCID 68859643, compoundYield 13%

Procedure

Using the general procedure above, 3-(3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 0.1423 g (0.941 mmol) of N-(4-picoly)ethylenediamine were reacted. The residue was chromatographed eluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v) then ethyl acetate/ethanol/triethylamine (9:3:2 v/v/v) to give 0.0162 g (13%) of the title compound: HPLC=92% pure.

Workup

  1. customwere reacted
  2. customThe residue was chromatographed
  3. washeluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v)

Sources & evidence

ORD record
ord-e8a55f3cc85c462eb471a80e5bf6fbdd
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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