N,N-Diethyl-1,3-propanediamine → HCID 68859661, compound

HRID 1783541Notes

Reaction equation

HRID 1783541 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16](S(C)=O)=[N:17][CH:18]=3)[NH:13][C:12]2=[O:24])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH2:25]([N:27]([CH2:30][CH2:31][CH2:32][NH2:33])[CH2:28][CH3:29])[CH3:26]>>[CH2:25]([N:27]([CH2:28][CH3:29])[CH2:30][CH2:31][CH2:32][NH:33][C:16]1[N:15]=[C:14]2[NH:13][C:12](=[O:24])[N:11]([C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=3)[CH2:20][C:19]2=[CH:18][N:17]=1)[CH3:26]

Participants

3

Reactant 2

HCID 61011N,N-Diethyl-1,3-propanediamineHCID 570581323-(3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one

Product 1

HCID 68859661HCID 68859661, compoundYield 40%

Procedure

Using the general procedure above, 3-(3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 0.1121 g (0.861 mmol) of diethylaminopropylamine were reacted. The residue was chromatographed eluting with acetonitrile/ethanol/triethylamine (8:1:0.5 v/v/v) to give 0.0476 g (40%) of the title compound: HPLC=89% pure.

Workup

  1. customwere reacted
  2. customThe residue was chromatographed
  3. washeluting with acetonitrile/ethanol/triethylamine (8:1:0.5 v/v/v)

Sources & evidence

ORD record
ord-05819feff3b64c408fca4cd71fa216c9
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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