1-(3-Aminopropyl)-4-methylpiperazine → 3-(3,5-Dimethoxy-phenyl)-1-ethyl-7-[3-(4-methyl-piperazin-1-yl)-propylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one

HRID 1783543Notes

Reaction equation

HRID 1783543 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16](S(C)=O)=[N:17][CH:18]=3)[N:13]([CH2:24][CH3:25])[C:12]2=[O:26])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:27][N:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][NH2:37])[CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16]([NH:37][CH2:36][CH2:35][CH2:34][N:31]4[CH2:30][CH2:29][N:28]([CH3:27])[CH2:33][CH2:32]4)=[N:17][CH:18]=3)[N:13]([CH2:24][CH3:25])[C:12]2=[O:26])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

3

Reactant 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68858127HCID 68858127, compound

Product 1

HCID 688621973-(3,5-Dimethoxy-phenyl)-1-ethyl-7-[3-(4-methyl-piperazin-1-yl)-propylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-oneYield 57%

Procedure

Using the general procedure above, 3-(3,5-dimethoxy-phenyl)-1-ethyl-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 0.1142 g (0.726 mmol) of 3-(4-methyl-piperazin-1-yl)-propylamine were reacted. The residue was chromatographed over silica gel, eluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v), to give 0.0712 g (57%) of the title compound: HPLC=96% pure.

Workup

  1. customwere reacted
  2. customThe residue was chromatographed over silica gel
  3. washeluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v)

Sources & evidence

ORD record
ord-ea5d8470cf3043a3805c830ab12a5550
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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