4-(4-Methylpiperazin-1-yl)butan-1-amine → HCID 68858071, compound

HRID 1783544Notes

Reaction equation

HRID 1783544 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16](S(C)=O)=[N:17][CH:18]=3)[N:13]([CH2:24][CH3:25])[C:12]2=[O:26])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:27][N:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][CH2:37][NH2:38])[CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:20][C:19]3[C:14](=[N:15][C:16]([NH:38][CH2:37][CH2:36][CH2:35][CH2:34][N:31]4[CH2:30][CH2:29][N:28]([CH3:27])[CH2:33][CH2:32]4)=[N:17][CH:18]=3)[N:13]([CH2:24][CH3:25])[C:12]2=[O:26])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

3

Reactant 2

HCID 64841924-(4-Methylpiperazin-1-yl)butan-1-amineHCID 68858127HCID 68858127, compound

Product 1

HCID 68858071HCID 68858071, compoundYield 41%

Procedure

Using the general procedure above, 3-(3,5-dimethoxy-phenyl)-1-ethyl-7-methanesulfinyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 0.1253 g (0.732 mmol) of 4-(4-methyl-piperazin-1-yl)-butylamine were reacted. The residue was chromatographed over silica gel, eluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v), to give 0.0527 g (41%) of the title compound: HPLC=94% pure.

Workup

  1. customwere reacted
  2. customThe residue was chromatographed over silica gel
  3. washeluting with ethyl acetate/ethanol/triethylamine (9:2:1 v/v/v)

Sources & evidence

ORD record
ord-e9adf27b52734687b8682fddc049617a
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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