HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783555Generated: October 30, 2026
Thionyl Chloride → 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid chloride
https://huagongshe.com/reaction/1783555
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid | HCID 12784085 | — |
| Product | 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid chloride | HCID 53963650 | — |
Reaction Steps
To 3.5 (15.4 mmol) of 4-(isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid is added 9.0 mL (123.2 mmol) of thionyl chloride, and the reaction mixture is heated at 50° C. for 1 hour, cooled to room temperature, and concentrated. The residue is twice suspended in anhydrous toluene and concentrated to give a colorless solid, 4-(isopropylamino)-2-(methylthio) pyrimidine-5-carboxylic acid chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07501425B1 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-3b250297335942b299c47a4902d0c23c |
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| Source note | uspto-grants-2009_03 |
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